Last edited by Nilar
Thursday, July 23, 2020 | History

6 edition of Chemistry and Molecular Aspects of Drug Design and Action found in the catalog.

Chemistry and Molecular Aspects of Drug Design and Action

  • 400 Want to read
  • 5 Currently reading

Published by CRC .
Written in English

    Subjects:
  • Pharmaceutical technology,
  • Science,
  • Science/Mathematics,
  • Pharmacy,
  • Science / Chemistry / General,
  • Pharmacology,
  • Chemistry - General,
  • Chemistry, Pharmaceutical,
  • Design,
  • Drugs,
  • Pharmaceutical chemistry

  • Edition Notes

    ContributionsE. A. Rekka (Editor), P. N. Kourounakis (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages360
    ID Numbers
    Open LibraryOL9315605M
    ISBN 100849390060
    ISBN 109780849390067

    Title:Molecular Aspects of the RT/drug ctive of Dual Inhibitors. VOLUME: 19 ISSUE: 10 Author(s):Simona Distinto, Elias Maccioni, Rita Meleddu, Angela Corona, Stefano Alcaro and Enzo Tramontano Affiliation:Department of Life and Environmental Sciences, University of Cagliari, Via Osped Cagliari, Italy. Chemical Biology & Drug Design is a peer-reviewed scientific journal dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design.

    Molecular Aspects of Anticancer Drug DNA Interactions Book Summary: This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists. The codification of the structural information of molecules through molecular descriptors and the subsequent data analysis allow establishing QSAR models (Quantitative Structure-Activity Relationship) that can be applied to the design and the virtual screening of new drugs.

    n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any.   Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and.


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Chemistry and Molecular Aspects of Drug Design and Action Download PDF EPUB FB2

Chemistry and Molecular Aspects of Drug Design and Action book. Chemistry and Molecular Aspects of Drug Design and Action book. Edited By E. Rekka, P. Kourounakis. Edition 1st Edition.

First Published eBook Published 28 April Pub. location Boca Raton. Imprint CRC by: 8. Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design.

Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field. Get this from a library. Chemistry and molecular aspects of drug design and action.

[E A Rekka; P N Kourounakis;] -- Drawing from synthetic chemistry, molecular modelling, computational biology, structural genomics, and pharmacology, this text explores medicinal chemistry.

It focuses on. - Classical Medicinal Chemistry - Drug Design, Chemical and Molecular Aspects of Drug Action - Drug Xenobiotic Metabolism - Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design.

Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design.

Offering insight from their own specialized research, these pioneers highlight the. Chemistry and Molecular Aspects of Drug Design and Action PDF By:E. Rekka,P. Kourounakis Published on by CRC Press. An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed.

Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Classical Medicinal Chemistry Drug Design, Chemical and Molecular Aspects of Drug Action Drug Xenobiotic Metabolism Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the.

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.

The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. Structural effects on drug action 1. Sequence of events after drug administration 2.

Physico-chemical properties that are related to drug action 3. Structurally Non-Specific Drugs 4. Structurally Specific Drugs 5. Role and types of chemical bonding involved in drug-target interactions 6. Steric factors and pharmacological activity. Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules ().

Compounds used as medicines are most often organic compounds. Rekka / Kourounakis, Chemistry and Molecular Aspects of Drug Design and Action,Buch, Bücher schnell und portofrei.

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.

This new edition includes updates to all Reviews: The author provides an extensive discussion of drug candidate optimization without the aid of molecular modeling, wherein the approaches presented are logically based and thus quite accessible to the reader.

"The Organic Chemistry of Drug Design and Drug Action" offers valuable and in-depth suggestions concerning many facets of drug discovery. The initial reductionist drug design approach (i.e., the “one target, one drug” paradigm) has been the driving force for many years in drug discovery.

With the recent advances in molecular biology and genomics technologies, the focus is shifting toward “drug-holistic” systems based approaches (i.e., systems chemical biology). New molecular modeling approaches, driven by rapidly improving computational platforms, have allowed many success stories for the use of computer-assisted drug design in the discovery of new mechanism-or structure-based drugs.

In this overview, we highlight three aspects of the use of molecular docking. This book contains an overview focusing on the research area of enzyme inhibitors, molecular aspects of drug metabolism, organic synthesis, prodrug synthesis, in silico studies and chemical compounds used in relevant approaches.

The book deals with basic issues and some of the recent developments in medicinal chemistry and drug by: 8. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding.

Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. About the Journal Aims and Scope.

The Journal of Medicinal Chemistry and Drug Design (JMCDD) (ISSN ) presents up-to-date coverage of advanced drug systems and their applications in medicine. Moreover, it brings the latest advances in fast-moving areas such as new drug approvals, covering all aspects of theory, research and application of diverse disciplines about Medicinal Chemistry.

The course is intended for students who have a background in chemistry and interested in the process of drug discovery. The intended outcome is to train students on various aspects of new drug discovery/development, drug screening, target identification, lead discovery, optimization and the molecular basis of drug design and drug action.

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures anReviews: 1.

In the theoretical chemistry area there are some strategies that are promising in relation to the design of new drugs, such as rational design, which consists of using information in different.This volume covers several aspects of rational drug design, such as synthesis of novel bioactive drugs; development and application of new methodologies; computational methods valuable for the establishment of new approaches in drug discovery; and the effects of physical-chemical and ADMET properties of the designed potential drugs.